Mithilesh Mishra is a professor at TIFR. He is interested in understanding the mechanism underlying the process of cell division and its...
Precise Mechanics of Cell Division: To divide, or not to divide
How does a cell know exactly where to divide? How does it find its precise middle? And what are the various paradigms of division that exist?
The beauty of science lies as much in the scientific discovery as in the question!
The latest estimate seems to say that there are 37.2 trillion cells in our body. Imagine this - each one knows how to divide exactly down the middle, with utter precision. And this is true across organisms and systems. So while each of us must have learned something about cell division in school, it remains an open area of enquiry as we seek to understand the biophysics that drive cell division.
We are delighted to invite Mithilesh Mishra - biophysicist and professor - to Mumbai Local, to take us through the exquisitely beautiful world of cells and the even smaller nano-machines that drive their division. He will share with us how research happens in this area, the discoveries about division that have been made, and the open questions that are still driving research.
Look forward to an evening of deep diving into the fascinating, complex and precise micro-world of cells. We will learn something about the nature and process of cell-division. As importantly, we will journey a little bit with the process of scientific enquiry and discovery, and share in the wonder that drives this process.
See you on Sunday, 13th August, 5:30 pm at Bhau Daji Lad Museum. And in keeping with the people-driven nature of Mumbai Local, do please send this email on to at least 5 of your friends who would be interested - the more the merrier!
@ MCubed Library, Bandra (W) - 1st Sat, 5 pm
@ Dr Bhau Daji Lad Museum, Byculla (E) - 2nd Sun, 5 pm
@ Kitab Khana, Fort - 3rd Fri, 5:30 pm
Mithilesh Mishra is a professor at TIFR. He is interested in understanding the mechanism underlying the process of cell division and its regulation. He uses a combination of in vitro and in vivo approaches including genetic, cellular, molecular and mathematical approaches to understand the assembly and function of the cell division apparatus. He uses the fission yeast as a simple model system to carry out most of their studies. As the process of cytokinesis and its regulation is mechanistically conserved, their findings should be applicable to understanding how cell division is controlled in human cells. Failure to complete cytokinesis results in aneuploidy associated with infertility, developmental defects and genetic instability that often lead to cancer. Hence, studying cytokinesis has important implications for cell proliferation and differentiation in normal development and also in disease conditions.